Certificate of Analysis Search Library
A peptide Certificate of Analysis should identify the material and batch, state the methods used, report relevant results and show an authorised review date. Search by product name or SKU, then confirm that the certificate matches the vial label. Never transfer results from one batch to another without documented justification.
Search current product-linked certificates
Enter a published product name or SKU. Results include products with a CoA attachment in the catalogue record. Open the document in a new tab and compare its batch or lot identifier with the label on the vial received.
The search is not a batch-release database and does not confirm that a particular order shipped the displayed batch. The order record, packing information, vial label and certificate must be reviewed together.
What a Certificate of Analysis is
A Certificate of Analysis is a controlled summary of tests and results associated with a defined material and batch. It should identify the product, batch, report or sample, relevant dates, methods or method references, results and authorised review.
The certificate supports a procurement and incoming-quality decision. It does not transfer responsibility for method suitability or experimental fitness from the receiving laboratory. A certificate can be accurate and still omit an attribute that a particular assay requires.
Treat downloaded certificates as controlled copies. Preserve the original file, source URL or system record, download date and any electronic signature information required by your quality procedure.
Match the batch before using the result
The most important check is simple: does the batch on the certificate match the batch on the physical material? Product names and SKUs can persist across many batches. Purity, impurity pattern, water, counter-ion and other results can change.
If the identifier is missing, truncated or inconsistent, quarantine the material. Do not edit the certificate or relabel the vial to create agreement. Contact the technical support desk with the order, product and photographs of the labels.
A historical certificate can support vendor history or method comparison. It cannot release a different batch without a documented and scientifically justified approach.
Review product identity
Confirm that the certificate describes the exact sequence or composition expected. Compare molecular formula, molecular weight, CAS number where relevant, terminal modifications, salt and other identifiers. An informal name should not override a conflicting sequence.
Mass spectrometry can support expected molecular mass. Examine whether the report shows observed mass, charge state or deconvolution and what molecular form was used for comparison. A close mass does not always prove complete sequence or stereochemistry.
For ambiguous names such as TB-500, exact sequence evidence is particularly important. Use the peptide glossary for definitions of adduct, monoisotopic mass, m/z and orthogonal method.
Review chromatographic purity
Identify the HPLC method or reference, column, wavelength, mobile phase or gradient where provided. Check the main peak, integrated impurities and reported area percentage. Ensure chromatogram sample identifiers connect to the certificate.
Relative HPLC area is not the same as net peptide content. Water, counter-ions and weakly detected components may not be represented proportionally. Co-eluting species can inflate the main peak. The HPLC quality guide provides a complete review checklist.
Do not compare purity figures from different methods as though they were identical measurements. If a contract specifies a method, confirm that the certificate uses it.
Assay and content basis
Where exact quantity matters, look for a content or assay result and its method. Nominal fill, gross cake mass and net peptide content are distinct. The formula and molecular weight used in molar calculations should match the supplied form.
An amino-acid analysis or another quantitative method may be used to estimate peptide content. Every method has uncertainty and assumptions. Record the value and basis used to prepare experimental concentrations.
If the certificate reports only HPLC purity, do not silently use that percentage as a quantitative assay correction. Ask the responsible scientist to decide how content uncertainty will be handled.
Additional quality attributes
Some projects require water content, residual solvents, counter-ion, elemental impurities, bioburden, endotoxin or sterility information. These attributes need their own suitable methods. They cannot be inferred from an HPLC chromatogram or mass spectrum.
Review units and acceptance limits. A result without a unit can be uninterpretable. “Pass” should connect to a defined criterion. Where a test is not performed, the certificate should not be read as an implicit pass.
The purchasing laboratory should define required attributes before ordering. For bulk or custom work, use the wholesale enquiry framework to include them in the quotation and specification.
Laboratory identity and accreditation
If testing is outsourced, identify the laboratory and report number. Confirm how the sample reached it and whether the tested sample represents the released batch. “Third-party tested” without laboratory, method and traceability information is weak.
ISO/IEC 17025 describes competence requirements for testing and calibration laboratories. Accreditation applies to a defined scope. Check whether the relevant method, matrix and range appear in that scope rather than assuming every report is accredited.
Accreditation strengthens confidence in systems and competence but does not make an unsuitable method suitable for every decision. The procuring laboratory still defines its requirement.
Electronic document checks
Open the file from the official product record or support response. Be cautious with renamed screenshots or compressed images that remove metadata and pages. Check page count, report number, revision and signature or approval details.
Do not upload certificates to public services that could expose confidential or controlled information. Store them in the organisation’s approved document system with access, backup and retention controls.
If a file changes after initial review, retain both versions and investigate the reason. A corrected certificate should identify the correction under the supplier’s document-control procedure.
Raw data and atypical results
A certificate is a summary and may not include every underlying injection, calculation or audit event. Where the purchasing risk justifies deeper review, agree whether chromatographic data, spectra, integration reports or method records can be supplied. Raw-data access can be limited by laboratory contracts and confidentiality, so set the expectation before purchase.
An out-of-specification, out-of-trend or atypical result should not be erased by simple retesting. A controlled investigation considers sample identity, preparation, instrument performance, method execution, data processing and manufacturing history. The final certificate should reflect the authorised disposition and any valid result replacement under the relevant procedure.
Do not average passing and failing values unless the specification and validated method support that calculation. A cosmetically improved result is not a scientifically justified result.
When no certificate appears
A missing search result can mean the product name was entered differently, the certificate has not been attached, the product is unpublished or no current certificate is available. It should not be filled with a certificate from a similar material.
Contact support with product, SKU and batch. If current documentation is an acceptance condition, wait for review before ordering or using the material. The product page should communicate the absence rather than hiding it.
Certificate review record
- Reviewer and review date.
- Product, SKU, batch and supplier.
- Certificate number, revision and file location.
- Identity evidence and expected molecular form.
- HPLC method context and reported purity.
- Content or assay basis used for calculations.
- Additional required quality attributes and results.
- Discrepancies, questions and resolution.
- Final quarantine, accept, restrict, retest or reject decision.
Continue with the storage protocol after acceptance and report any shipping discrepancy through the delivery policy. A well-reviewed certificate is part of traceability, not a replacement for it.